We report a case of an acute ST-segment elevation myocardial infarction in a affected person with traditional cardiac threat factors using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, likely secondary to high-dose testosterone. The affected person underwent successful percutaneous intervention of the right coronary artery. Physicians and patients ought to be conscious of the medical consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996).
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Erythrocytosis has been reported as a potential effect of testosterone, which may be helpful in sufferers with anemia. The biggest danger of erythrocytosis happens with injectable types of testosterone in contrast with transdermal preparations, especially in supraphysiologic doses. An improve of as a lot as 44% of the baseline hematocrit has been reported .
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Moreover, a part of endothelial dysfunction has been proposed, which can contribute to abnormal vessel reactivity. However, testosterone in physiologic doses could even be helpful in patients with angina , have larger ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood flow in men with established coronary artery disease . Therefore, an interplay of endogenous components of the patient’s threat profile as properly as the testosterone dosing could also be problems with whether antagonistic occasions occur.
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Rhoden EL, Morgentaler A. Risks of testosterone-replacement remedy and suggestions for monitoring. Testosterone alternative in hypogonadal males with angina improves ischaemic threshold and quality of life. Ajayi AAL, Mathur R, Halushka PV. Testosterone enhance human platelet thromboxane A2 receptor density and aggregation responses.
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